International Journal of Engineering Technology and Scientific Innovation
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Title:
THE EFFECT OF TRIGONELLA FOENUM-GRAECUM (FENUGREEK) ON THE BLOOD GLUCOSE, LIPID PROFILE AND Alpha-AMYLASE FOR DIABETIC ALBINO RATS COMPARED WITH GLIBENCLAMIDE DRUG.

Authors:
Laila E. Taha, Siham M. A. Bakhit, Abdalla Eltoum Ali, Alneil M. Hamza

Abstract:
Background: Diabetes is a metabolic syndrome characterized by hyperglycemia, hyper cholesterolemia and hyper triglyceridemia, Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. Objective: This study aimed to compare the hypoglycemic effect of antidiabetic drug (glibenclamide) and Trigonella foenum graecum aqueous extract. Materials & Methods: Twenty four albino rats were used in this experiment. Rats were assigned to 4 groups (N=6). All groups were fasted for 18 hrs. Group (1) was administered with glibenclamide (10 mg/kg b.w.), 3 groups were orally administered with different doses of Trigonella foenum graecum (fenugreek) seeds aqueous extract respectively, Blood samples were obtained to assess blood glucose, lipid profile and Alpha-amylase concentrations. Results: Obtained results from this study indicated that Trigonella foenum graecum (fenugreek) aqueous extract significantly decreased blood glucose level in treated groups received (200 and 400 mg/kg b.w.). Compared with glibenclamide which reduced blood glucose level below normal level. At the dose of 400 mg/kg b.w. of Trigonella foenum graecum (fenugreek) aqueous extract, the activity of Alpha-amylase was higher than control group which had been treated with glibenclamide. All groups registered low concentrations of cholesterol, triglycerides and HDL . Conclusion: It can be concluded from this study that the best dose was (200mg/kg-b.w) Trigonella foenum graecum (Fenugreek), aqueous extract have a hypoglycemic effect by reducing both blood glucose and Alpha-amylase enzyme.

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