Diabetes is a metabolic syndrome characterized by hyperglycemia, hyper cholesterolemia and
hyper triglyceridemia, Trigonella foenum-graecum (fenugreek) seeds have been documented as a
traditional plant treatment for diabetes.
Objective: This study aimed to compare the hypoglycemic effect of antidiabetic drug
(glibenclamide) and Trigonella foenum graecum aqueous extract.
Materials & Methods: Twenty four albino rats were used in this experiment. Rats were
assigned to 4 groups (N=6). All groups were fasted for 18 hrs. Group (1) was administered
with glibenclamide (10 mg/kg b.w.), 3 groups were orally administered with different doses
of Trigonella foenum graecum (fenugreek) seeds aqueous extract respectively, Blood samples
were obtained to assess blood glucose, lipid profile and Alpha-amylase concentrations.
Results: Obtained results from this study indicated that Trigonella foenum graecum
(fenugreek) aqueous extract significantly decreased blood glucose level in treated groups
received (200 and 400 mg/kg b.w.). Compared with glibenclamide which reduced blood glucose level below normal level. At the dose of 400 mg/kg b.w. of Trigonella foenum graecum
(fenugreek) aqueous extract, the activity of Alpha-amylase was higher than control group which
had been treated with glibenclamide. All groups registered low concentrations of cholesterol,
triglycerides and HDL .
Conclusion: It can be concluded from this study that the best dose was (200mg/kg-b.w)
Trigonella foenum graecum (Fenugreek), aqueous extract have a hypoglycemic effect by
reducing both blood glucose and Alpha-amylase enzyme.